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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
GUCY1A3
All Species:
33.64
Human Site:
Y510
Identified Species:
61.67
UniProt:
Q02108
Number Species:
12
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q02108
NP_000847.2
690
77452
Y510
I
T
M
L
N
A
L
Y
T
R
F
D
Q
Q
C
Chimpanzee
Pan troglodytes
XP_522169
734
81883
Y552
I
S
M
L
N
E
L
Y
T
R
F
D
H
Q
C
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_536590
746
83063
Y564
I
S
M
L
N
E
L
Y
T
R
F
D
H
Q
C
Cat
Felis silvestris
Mouse
Mus musculus
Q9ERL9
691
77555
Y510
I
T
M
L
N
A
L
Y
T
R
F
D
Q
Q
C
Rat
Rattus norvegicus
P19686
690
77548
Y509
I
T
M
L
N
A
L
Y
T
R
F
D
Q
Q
C
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001510214
690
77963
Y510
I
T
M
L
N
E
L
Y
T
L
F
D
Y
Q
C
Chicken
Gallus gallus
XP_420375
688
77848
Y508
I
T
M
L
N
E
L
Y
T
R
F
D
Y
Q
C
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
XP_002667138
626
69572
T454
D
I
P
I
H
D
A
T
R
D
V
I
L
V
G
Tiger Blowfish
Takifugu rubipres
NP_001027855
675
75480
V494
T
M
L
F
S
D
I
V
G
F
T
A
V
C
S
Fruit Fly
Dros. melanogaster
Q07093
676
75644
Y495
I
S
M
L
E
G
L
Y
K
D
F
D
E
F
C
Honey Bee
Apis mellifera
NP_001011650
699
78655
Y520
I
N
M
L
Q
N
L
Y
E
Q
F
D
S
F
C
Nematode Worm
Caenorhab. elegans
O02298
688
78384
P482
Y
M
I
V
G
G
V
P
E
R
C
E
N
H
A
Sea Urchin
Strong. purpuratus
P16065
1125
126238
Y943
V
N
L
L
N
D
L
Y
T
L
F
D
A
I
I
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
47.9
N.A.
47.3
N.A.
89.5
89.2
N.A.
87.5
84
N.A.
39.1
58.9
34.2
35
29.5
22.6
Protein Similarity:
100
63
N.A.
62.4
N.A.
94.9
94.9
N.A.
93.4
92.3
N.A.
54.3
73.6
53.3
55.3
48.2
36.3
P-Site Identity:
100
80
N.A.
80
N.A.
100
100
N.A.
80
86.6
N.A.
0
0
53.3
53.3
6.6
46.6
P-Site Similarity:
100
86.6
N.A.
86.6
N.A.
100
100
N.A.
80
86.6
N.A.
13.3
20
66.6
60
33.3
60
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
24
8
0
0
0
0
8
8
0
8
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
8
0
0
8
70
% C
% Asp:
8
0
0
0
0
24
0
0
0
16
0
77
0
0
0
% D
% Glu:
0
0
0
0
8
31
0
0
16
0
0
8
8
0
0
% E
% Phe:
0
0
0
8
0
0
0
0
0
8
77
0
0
16
0
% F
% Gly:
0
0
0
0
8
16
0
0
8
0
0
0
0
0
8
% G
% His:
0
0
0
0
8
0
0
0
0
0
0
0
16
8
0
% H
% Ile:
70
8
8
8
0
0
8
0
0
0
0
8
0
8
8
% I
% Lys:
0
0
0
0
0
0
0
0
8
0
0
0
0
0
0
% K
% Leu:
0
0
16
77
0
0
77
0
0
16
0
0
8
0
0
% L
% Met:
0
16
70
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
16
0
0
62
8
0
0
0
0
0
0
8
0
0
% N
% Pro:
0
0
8
0
0
0
0
8
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
8
0
0
0
0
8
0
0
24
54
0
% Q
% Arg:
0
0
0
0
0
0
0
0
8
54
0
0
0
0
0
% R
% Ser:
0
24
0
0
8
0
0
0
0
0
0
0
8
0
8
% S
% Thr:
8
39
0
0
0
0
0
8
62
0
8
0
0
0
0
% T
% Val:
8
0
0
8
0
0
8
8
0
0
8
0
8
8
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
8
0
0
0
0
0
0
77
0
0
0
0
16
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _